Metabolomic profile of acute respiratory distress syndrome of different etiologies

摘要

In a recent study, we reported the metabolic alterations related to acute respiratory distress syndrome (ARDS) in patients with influenza A pneumonia (IAP) [ ]. We hypothesized that other types of acute lung injury causing ARDS may share the same metabolic alterations. As proof of concept, we have analyzed the metabolomic profiles of patients with and without ARDS induced by (SPP) (ARDS = 13; no ARDS = 17) or IAP (ARDS = 12; no ARDS = 18). Some of the results of these studies have been previously reported in the form of an abstract [ ]. Patients with SPP were older (  p 1, ]. We quantified 16 characteristic serum metabolites, and statistical significance was determined using a Bonferroni-corrected Student test, assuming unequal variance, with