Effects of PI3‐k/Akt short hairpin RNA on proliferation fibronectin production and synthesis of thrombospondin‐1 and transforming growth factor‐β1 in glomerular mesangial cells induced by sublytic C5b‐9 complexes

摘要

To explore proliferation of glomerular mesangial cells (GMC) and secretion of extracelluar matrix (fibronectin induced by sublytic C5b‐9 complexes), and then ascertain the role of phosphatidylinositol 3‐kinase (PI3‐k)/Akt signal pathway in these processes, by using small hairpin RNAs.