Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease

摘要

Peripheral artery disease ( ) is a vascular disease affecting peripheral circulation. Recently, genome‐wide association studies revealed a relationship between single nucleotide polymorphisms ( s) in (a disintegrin and metalloprotease with thrombospondin motif 7) and atherosclerosis. In this study, we aimed to determine 7 expression in peripheral blood mononuclear cells ( s) and the frequency of rs1994016 and rs3825807 polymorphisms in a sample of Turkish patients with , and to evaluate the association of matrix metalloproteinase ( ) levels with development.