The C ( :8), C ( :9), and ( :51) antigens are encoded by alleles at the Cc locus of the Rh system, where C and C are considered low‐frequency antigens and antithetical to the high‐frequency antigen . The frequency of C ( :8) is approximately 2% in Caucasians, 1% in Black people, 4% in Finns, and 9% in Latvians. The aim of this study was to determine the frequency of RhD+ phenotypes in a population of southeast Brazilian blood donors and to perform a molecular study to distinguish the and alleles, responsible for the C and C expressions, respectively.
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