Time‐resolved fluorescent immunoassay‐based combined detection of procalcitonin C‐reactive protein heparin binding protein and serum amyloid A1 to improve the diagnostic accuracy of early infection

摘要

Serological tests are indispensable in the diagnosis of early infection. At present, only procalcitonin (PCT) and C‐reactive protein (CRP) are commonly used in clinical practice. Recently, serum amyloid A1 (SAA1) and heparin binding protein (HBP) have been shown to be new biomarkers, because SAA1 is highly sensitive and specific for viral infections, and HBP is predictive for septic shock. In this study, PCT, CRP, HBP, and SAA1 were detected in different combinations to improve the diagnostic accuracy of early infection using the biotin‐avidin amplifying system‐based time‐resolved fluorescent immunoassay (BA‐TRFIA).