Helicobacter pylori seropositivity and its relationship with serum malondialdehyde and lipid profile in preeclampsia

摘要

: To investigate seropositivity rate in preeclamptic and healthy pregnants. Additionally, we compared serum malondialdehyde (MDA) levels and lipid profile between ‐positive and negative cases. : This study included 53 preeclamptic and 30 healthy pregnants. Serum levels of total cholesterol (TC), triglyceride (TG), high‐density lipoprotein (HDL‐C) and low‐density lipoprotein (LDL‐C), MDA, and Ig G antibodies were measured. : Preeclampsia group had higher serum MDA levels compared with healthy pregnants ( <0.001). While the rate of seropositivity was 43/53 (81%) in the preeclampsia group, this was 18/30 (% 60) in normal pregnants (odds ratio (OR), 2.86; 95% confidence interval (CI), 1.05–7.82; =0.036). We further divided the preeclampsia group as ‐positive and ‐negative subgroups. In ‐positive group, serum TC ( <0.01) and LDL‐C ( <0.01) levels were significantly higher than those of ‐negative group. Mean MDA concentration was higher in ‐positive group than that of ‐negative group ( <0.001). : ‐positive pregnants may have a high risk for preeclampsia and may be one of the causes for high MDA levels in preeclampsia. J. Clin. Lab. Anal. 23:219–222, 2009. © 2009 Wiley‐Liss, Inc.