Empirical evidence for definitions of episode remission recovery relapse and recurrence in depression: a systematic review

摘要

For the past quarter of a century, Frank ’s (1991) consensus-based definitions of major depressive disorder (MDD) episode, remission, recovery, relapse and recurrence have been the paramount driving forces for consistency in MDD research as well as in clinical practice. This study aims to review the evidence for the empirical validation of Frank ’s proposed concept definitions and to discuss evidence-based modifications.