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The Histone Lysine-specific Demethylase 1 Inhibitor SP2509 ExertsCytotoxic Effects against Renal Cancer Cells through Downregulation of Bcl-2 andMcl-1

机译：组蛋白赖氨酸特异性脱甲基酶1抑制剂SP2509发挥作用通过下调Bcl-2和Bcl对肾癌细胞的细胞毒作用Mcl-1

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期刊名称 Journal of Cancer Prevention
作者
Kaixin Wu; Seon Min Woo; Taeg Kyu Kwon;
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作者单位

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年(卷),期 2020(25),2
年度 2020
页码 -1
总页数 8
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
KDM1A; SP2509; Bcl-2; Mcl-1; Apoptosis;

机译：KDM1A;SP2509;Bcl-2;Mcl-1;细胞凋亡;

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专利

1. Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells [J] . VasilatosS.N., KatzT.A., OesterreichS., Carcinogenesis . 2013,第6期

机译：赖氨酸特异性脱甲基酶1（LSD1）和组蛋白脱乙酰基酶之间的串扰介导HDAC抑制剂在人乳腺癌细胞中的抗肿瘤功效
2. Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities [J] . Dante Rotili, Stefano Tomassi, Mariarosaria Conte, Journal of Medicinal Chemistry . 2014,第1期

机译：泛组蛋白去甲基化酶抑制剂同时针对Jumonji C和赖氨酸特定的脱甲基酶显示高抗癌活性。
3. The histone demethylase lysine-specific demethylase-1–mediated epigenetic silence of KLF2 contributes to gastric cancer cell proliferation, migration, and invasion [J] . Ruizhong Fang, Jian Xu, Hai Lin, Tumour biology : . 2017,第4期

机译：组蛋白脱甲基酶赖氨酸特异性脱甲基酶-1介导的KLF2表观遗传沉默有助于胃癌细胞的增殖，迁移和侵袭
4. Ultra High-throughput MS Methods for the Discovery of Histone Demethylase Inhibitors [C] . John M. Peltier, Keeley Murphy, Nicole M. White, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：用于发现组蛋白去甲基酶抑制剂的超高通量MS方法
5. Lysine-specific Histone Demethylase 1A as a Regulator of Reactive Oxygen Species Response in Cancer Therapy [D] . Mudambi, Shaila. 2018

机译：赖氨酸特异性组蛋白去甲基酶1a作为癌症治疗中活性氧物质反应的调节剂
6. Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells [O] . Shauna N. Vasilatos, Tiffany A. Katz, Steffi Oesterreich, -1

机译：赖氨酸特异性脱甲基酶1（LSD1）和组蛋白脱乙酰基酶之间的串扰介导HDAC抑制剂在人乳腺癌细胞中的抗肿瘤功效
7. Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines [O] . Sergiy Konovalov, Ivan Garcia-Bassets 2013

机译：人类卵巢肿瘤中赖氨酸特异性脱甲基酶1（LSD1）mRNA的水平分析以及化学LSD1抑制剂对卵巢癌细胞系的影响

The Histone Lysine-specific Demethylase 1 Inhibitor SP2509 ExertsCytotoxic Effects against Renal Cancer Cells through Downregulation of Bcl-2 andMcl-1

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