We were excited to read the paper by Hughes et al. ( ) examining DNA methylation (DNAm) age acceleration and measures of socioeconomic position using a life-course approach. They found that, compared with participants whose parents worked in professional or managerial occupations, individuals with unemployed parents or parents in unskilled positions in childhood had elevated epigenetic age acceleration later in life. These findings are interesting and may implicate early-life circumstances with alterations in mortality-associated biomarkers.
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