Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

摘要

Effects of obesity on echocardiographic parameters in monocrotaline (MCT)-induced pulmonary hypertension (PH) in male Zucker rats. Echocardiography was performed after 5 weeks of either normal saline (NS) (NS Lean (  = 10); NS Obese (  = 9–10)) or monocrotaline (MCT Lean (  = 11); MCT Obese (  = 8–10)) treatment in lean and obese male Zucker rats. Lean and obese male Zucker rats are shown. Body mass index (BMI) of lean and obese male Zucker rats and ( ) different echocardiographic parameters are given. RVID = right ventricular internal diameter, RVWT = right ventricular wall thickness, PAAT = pulmonary artery acceleration time, PAET = pulmonary artery ejection time, TAPSE = tricuspid annular plane systolic excursion. Data are presented as mean ± SEM (  = 8–11).  $compared to normal saline