Inhibition of microRNA-451 is associated with increased expression of Macrophage Migration Inhibitory Factor and mitgation of the cardio-pulmonary phenotype in a murine model of Bronchopulmonary Dysplasia

摘要

Expression of miR-451 is upregulated by hyperoxia in MLECs and in murine lung tissues. RNA was extracted from MLECs grown in room air and exposed to hyperoxia (95% O ) for 16 h. miR-451 expression was evaluated using RT-qPCR.  = 3, in each group. RT-qPCR was performed on RNA extracted from the lungs of NB room air (RA) and BPD mice.  = 5, in each group. MLECs: mouse lung endothelial cells, RA: room air, Hyp – 16 h: hyperoxia for 16 h; NB: newborn; RA: room air; BPD: bronchopulmonary dysplasia. **  p