Comparing the Diagnostic Accuracy of Anti-Müllerian Hormone and Follicle Stimulating Hormone in Detecting Premature Ovarian Failure in Iraqi Women by ROC Analysis

摘要

In women premature ovarian failure (POF) is a devastating disease impacting women under the age of 40. This involves a significant decrease in a women’s quantity and quality of oocytes, or ovarian reserve (OR). POF can result in long-term physical and psychological health consequences. The earlier treatment can occur to manage this disease, the less likely the individual is going to suffer from the potential consequences. Accurate diagnosis is a critical proponent to ensuring immediate care. A traditional diagnostic marker includes follicular stimulating hormone (FSH). This individual test cannot be used to make a diagnosis in isolation due to the large variability in FSH levels among different women, and throughout a women’s menstrual cycle. Anti-Müllerian hormone (AMH) is an alternative diagnostic marker for determining a women’s OR. Serum levels of AMH have been shown to be associated with the size of the resting primordial follicle pool. When the levels of AMH are low, this is generally considered to be an indicator of a decline in fertility. In this study, we examined the specificity, sensitivity and accuracy of the FSH assay, against the more recently emerged AMH assay for diagnosing and predicting POR via Receiver Operator Characteristic curve (ROC) analysis.