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Does Intensive Treatment Select for Praziquantel Resistance in High-Transmission Settings? Parasitological Trends and Treatment Efficacy Within a Cluster-Randomized Trial

机译：在高透射环境下强化治疗是否会选择对吡喹酮的耐药性？整群随机试验中的寄生虫学趋势和治疗效果

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摘要

Praziquantel mass drug administration (MDA) is recommended in schistosomiasis-endemic areas. Animal models demonstrate parasite resistance to praziquantel after repeated exposure.

机译：建议在血吸虫病流行地区使用吡喹酮大规模药物管理（MDA）。动物模型表明，反复接触后寄生虫对吡喹酮有抗药性。

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期刊名称 Open Forum Infectious Diseases
作者
John Vianney Tushabe; Lawrence Lubyayi; Joel Sserubanja; Prossy Kabuubi; Elson Abayo; Samuel Kiwanuka; Jacent Nassuuna; James Kaweesa; Paul Corstjens; Govert van Dam; Richard E Sanya; William Ssenyonga; Edridah Muheki Tukahebwa; Narcis B Kabatereine; Alison M Elliott; Emily L Webb; LaVIISWA trial team;
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年(卷),期 2020(7),4
年度 2020
页码 -1
总页数 8
原文格式 PDF
正文语种
中图分类病毒传染病;
关键词
drug resistance; mass drug administration; praziquantel; schistosomiasis;

机译：耐药性;大量给药;吡喹酮;血吸虫病;

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1. Does Intensive Treatment Select for Praziquantel Resistance in High-Transmission Settings? Parasitological Trends and Treatment Efficacy Within a Cluster-Randomized Trial [J] . John Vianney Tushabe, Lawrence Lubyayi, Joel Sserubanja, Open Forum Infectious Diseases . 2020,第4期

机译：是否在高传输环境中为吡喹酮进行了密集的治疗选择？血液组合试验中的寄生趋势和治疗疗效
2. Corrections to Efficacy of oseltamivir treatment started within 5 days of symptom onset to reduce influenza illness duration and virus shedding in an urban setting in Bangladesh: A randomised placebo-controlled trial [Lancet Infect Dis 14 (2014) 109-18] [J] . The Lancet infectious diseases . 2014,第2期

机译：在孟加拉国的城市环境中，开始出现症状的5天之内开始对奥司他韦治疗的有效性进行校正，以减少流感病的持续时间和减少病毒脱落：一项随机安慰剂对照试验[Lancet Infect Dis 14（2014）109-18]
3. Efficacy of oseltamivir treatment started within 5 days of symptom onset to reduce influenza illness duration and virus shedding in an urban setting in Bangladesh: A randomised placebo-controlled trial [J] . FryA.M., GoswamiD., NaharK., The Lancet infectious diseases . 2014,第2期

机译：在孟加拉国的城市环境中，出现症状后5天内就开始使用奥司他韦治疗，以减少流感病的持续时间和减少病毒的释放：一项随机安慰剂对照试验
4. Evaluation of the efficacy of RUTI and ID93/GLA-SE vaccines in tuberculosis treatment: in silico trial through UISS-TB simulator [C] . Giulia Russo, Francesco Pappalardo, Miguel A. Juarez, IEEE International Conference on Bioinformatics and Biomedicine . 2019

机译：评估RUTI和ID93 / GLA-SE疫苗在结核病治疗中的功效：通过UISS-TB模拟器进行的计算机模拟试验
5. Some sequential and two -stage procedures for selecting the best treatment in clinical trials. [D] . Liu, Chengan. 2005

机译：在临床试验中选择最佳治疗方法的一些顺序和两阶段程序。
6. New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel [O] . Martin Walker, Tarub S. Mabud, Piero L. Olliaro, 2016

机译：测量驱虫药功效的新方法：儿童血吸虫感染对吡喹酮治疗的寄生虫学反应
7. Does Intensive Treatment Select for Praziquantel Resistance in High-Transmission Settings? Parasitological Trends and Treatment Efficacy Within a Cluster-Randomized Trial [O] . John Vianney Tushabe, Lawrence Lubyayi, Joel Sserubanja, 2020

机译：是否在高传输环境中为吡喹酮进行了密集的治疗选择？血液组合试验中的寄生趋势和治疗疗效
8. Developing Treatment, Treatment Validation, and Treatment Scope in the Setting of an Autism Clinical Trial. [R] . Novotny, S. 2013

机译：在自闭症临床试验设置中开发治疗，治疗验证和治疗范围。

Does Intensive Treatment Select for Praziquantel Resistance in High-Transmission Settings? Parasitological Trends and Treatment Efficacy Within a Cluster-Randomized Trial

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