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miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer

机译：miR-145通过抑制肝癌恶性腹水中PI3K / Akt / mTOR / p70S6K /HIF-1α途径的激活来抑制Th9细胞分化

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Our previous experiments confirmed that T helper type 9 (Th9) cells were involved in the occurrence and development of malignant ascites caused by liver cancer. The current study investigated the mechanism underlying microRNA (miR-145)-mediated inhibition of Th9 cells in an malignant ascites model with liver cancer.

机译：我们以前的实验证实T辅助9型（Th9）细胞参与了由肝癌引起的恶性腹水的发生和发展。目前的研究调查了在肝癌恶性腹水模型中，microRNA（miR-145）介导的Th9细胞抑制作用的机制。

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期刊名称 OncoTargets and therapy
作者
You-Yi Huang; Hai-Xing Jiang; Qiu-Yue Shi; Xin Qiu; Xi Wei; Xiang-Lian Zhang; Shan-Yu Qin;
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作者单位

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年(卷),期 2020(13),-1
年度 2020
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类应用微生物学;肿瘤学;
关键词
miR-145; Th9 cells; PI3K/Akt; HIF-1α; hepatoma malignant ascites;

机译：miR-145;Th9细胞;PI3K / Akt;HIF-1α;肝癌恶性腹水;

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专利

1. miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer [J] . You-Yi Huang, Hai-Xing Jiang, Qiu-Yue Shi, OncoTargets and therapy . 2020,第2期

机译：miR-145通过抑制来自肝癌的恶性腹水中的PI3K / AKT / mTOR / P70S6K / HIF-1α途径的激活来抑制TH9细胞分化
2. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells [J] . Hong-Wei Zhang, Jin-Jiao Hu, Ruo-Qiu Fu, Scientific reports. . 2018,第1期

机译：类黄酮通过下调PI3Kγ介导的PI3K / AKT / mTOR / p70S6K / ULK信号通路抑制人乳腺癌细胞的增殖并诱导细胞凋亡和自噬
3. Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells [J] . Yuefan Ma, Zihan Xiu, Zhiyuan Zhou, Journal of Cancer . 2019,第9期

机译：细胞松弛素H通过抑制非小细胞肺癌细胞中PI3K / AKT / P70S6K和ERK1 / 2信号通路的HIF-1α蛋白积累和VEGF表达抑制血管生成。
4. Label-free phosphoproteomics method to investigate signaling pathways downstream of novel PI3K/mTOR inhibitors in cancer cells [C] . Pedro Casado, Juan Carlos Rodriguez-Prados, Sabina Cosulich, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：无标记的磷蛋白质方法，用于研究新型PI3K / MTOR抑制剂在癌细胞中的信号通路
5. Sensitivity of MCF-7 breast cancer cells to anticancer drugs is decreased by activation of the PI3K/PDK/Akt signal transduction pathway. [D] . Navolanic, Patrick M. 2004

机译：通过激活PI3K / PDK / Akt信号转导途径，MCF-7乳腺癌细胞对抗癌药物的敏感性降低。
6. Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells [O] . Gi Dae Kim 2017

机译：山emp酚通过抑制内皮细胞中的ERK / p38 MAPK和PI3K / Akt / mTOR信号通路抑制HIF-1α和VEGFR2激活来抑制血管生成。
7. Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells [O] . Gi Dae Kim 2017

机译：Kaempferol通过ERK / P38 MAPK和PI3K / AKT / MTOR信号传导途径抑制HIF-1α和VEGFR2活化来抑制血管生成，通过内皮细胞

miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer

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