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RSF-1 siRNA Enhances Tumor Radiosensitivity in Cervical Cancer via Enhanced DNA Damage Cell Cycle Redistribution and Promotion of Apoptosis

机译：RSF-1 siRNA通过增强DNA损伤细胞周期重新分布和促进凋亡来增强宫颈癌的放射敏感性。

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摘要

Remodeling and spacing factor-1 (RSF-1) is an identified tumor biomarker that is overexpressed in a variety of human cancers, but its effect on radiotherapy remains unclear. In this study, we aimed to explore the effect of RSF-1 siRNA on sensitizing cervical cancer cells to radiation and its underlying mechanism.

机译：重塑和间隔因子-1（RSF-1）是一种已鉴定的肿瘤生物标志物，在多种人类癌症中均过表达，但其对放射治疗的作用仍不清楚。在这项研究中，我们旨在探讨RSF-1 siRNA对子宫颈癌细胞辐射敏感性的影响及其潜在机制。

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期刊名称 OncoTargets and therapy
作者
Jing Tian; Enqi Kong; Xiangyu Wang; Zhaoguang Xie; Cherry Yin-Yi Chang; Jim Jinn-Chyuan Sheu; Quan Hao; Li Sun;
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作者单位

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年(卷),期 2020(13),-1
年度 2020
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类应用微生物学 ; 肿瘤学 ;
关键词
RSF-1; cervical cancer; radiotherapy; DNA damage;

机译：RSF-1;宫颈癌;放射治疗;DNA损伤;

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专利

1. RSF-1 siRNA Enhances Tumor Radiosensitivity in Cervical Cancer via Enhanced DNA Damage, Cell Cycle Redistribution, and Promotion of Apoptosis [J] . Jing Tian, Enqi Kong, Xiangyu Wang, OncoTargets and therapy . 2020 ,第2期

机译：RSF-1 siRNA通过增强的DNA损伤，细胞周期再分配和促进凋亡，增强宫颈癌中的肿瘤放射敏感性
2. GLUT-1 siRNA Enhances Radiosensitization Of Laryngeal Cancer Stem Cells Via Enhanced DNA Damage, Cell Cycle Redistribution, And Promotion Of Apoptosis In Vitro And In Vivo [J] . Jiang-Tao Zhong, Qi Yu, Shui-Hong Zhou, OncoTargets and therapy . 2019 ,第2期

机译：通过增强的DNA损伤，细胞周期再分配和体外凋亡，细胞周期再分配和促进细胞促进增强喉癌干细胞的射孔敏感性
3. Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa-light-chain-enhancer of activated B cell signaling [J] . Roy Rituparna, Pal Debolina, Sur Subhayan, Phytotherapy research: PTR . 2019 ,第4期

机译：Pongapin和Karanjin，Pongamia Pinnata的呋喃三鳍，通过鉴别反应性氧物种调制，DNA损伤和核因子κ轻链 - 激活B细胞信号传导的核癌细胞诱导G2 / M抑制和凋亡
4. Over-expression of Smac Gene Enhances the Effect ofRadiation Induced Apoptosis in Human Cervical Cancer Cell Line HeLa [C] . ZHAO Baofeng, TIAN Mei, RUAN Jianlei, . 2006

机译：Smac基因的过量表达增强了宫颈癌HeLa细胞辐射诱导的凋亡作用
5. Mechanism of 3,3'-diindolylmethane-induced cell death in human C33A cervical cancer cells: Induction of endoplasmic reticulum stress, apoptosis and the role of growth-arrest and DNA-damage genes [D] . Han, Jing Y. 2009

机译：3,3'-二吲哚基甲烷诱导的人C33A宫颈癌细胞死亡的机制：内质网应激，细胞凋亡以及生长停滞和DNA损伤基因的作用
6. GLUT-1 siRNA Enhances Radiosensitization Of Laryngeal Cancer Stem Cells Via Enhanced DNA Damage Cell Cycle Redistribution And Promotion Of Apoptosis In Vitro And In Vivo [O] . Jiang-Tao Zhong, Qi Yu, Shui-Hong Zhou, 2019

机译：GLUT-1 siRNA通过增强的DNA损伤细胞周期重新分布以及促进体内外凋亡来增强喉癌干细胞的放射敏感性。
7. >RSF-1 siRNA Enhances Tumor Radiosensitivity in Cervical Cancer via Enhanced DNA Damage, Cell Cycle Redistribution, and Promotion of Apoptosis [O] . Jing Tian, Enqi Kong, Xiangyu Wang, 2020

机译：> RSF-1 siRNA通过增强的DNA损伤，细胞周期再分配和凋亡促进来增强宫颈癌中的肿瘤放射敏感性
8. 5-AED Enhances Survival of Irradiated Mice in a G-CSF-Dependent Manner, Stimulates Innate Immune Cell Function, Reduces Radiation-Induced DNA Damage and Induces Genes that Modulate Cell Cycle Progression and Apoptosis. [R] . Grace, M. B., Singh, V. K., Rhee, J. G., 2012

机译：5-aED以G-CsF依赖性方式增强辐照小鼠的存活，刺激先天免疫细胞功能，减少辐射诱导的DNa损伤并诱导调节细胞周期进展和细胞凋亡的基因。

RSF-1 siRNA Enhances Tumor Radiosensitivity in Cervical Cancer via Enhanced DNA Damage Cell Cycle Redistribution and Promotion of Apoptosis

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