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Evaluation of expression of vitamin D receptor related lncRNAs in lung cancer

机译:肺癌中与维生素D受体相关的lncRNA表达的评估

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摘要

Lung cancer as the most common cancer in the world is associated with high rate of mortality. Previous studies have detected expression of vitamin D receptor (VDR) in lung cancer tissues and reported significant of this gene in determination of patients' survival. Methods: In the current study, we assessed expression of and five long non-coding RNAs (lncRNAs) which have been associated with VDR ( , , , ) in 32 pairs of lung cancer tissues and adjacent non-cancerous tissues (ANCTs) using real time PCR method. Expression of was significantly decreased in tumor tissues obtained from male patients compared with their matched ANCTs (ER = 0.31, P value = 0.02). However, this pattern was not detected in female subjects (ER = 0.93, P value = 0.94). Expression of LINC00346 was significantly decreased in tumoral tissues compared with ANCTs (Expression ratio (ER) = 0.38, P value = 0.03). When evaluating expression of this lncRNA based on the sex of patients, differences in its expression was only significant among males (ER = 0.3, P value = 0.04). expression was significantly associated with sex of patients in a way that most male patients exhibited down-regulation of this gene in their tumor tissue samples compared with the paired ANCTs (P = 0.03). Expression levels of LINC00346 could discriminate lung cancer tissues from ANCTs with sensitivity of 83.3% and specificity of 52.4%. Correlations between expressions of and other genes were all significant in tumoral tissues but insignificant in ANCTs. The current investigation potentiates and LINC00346 as possible participants in the pathogenesis of lung cancer.
机译:肺癌是世界上最常见的癌症,其死亡率很高。先前的研究已经检测到了肺癌组织中维生素D受体(VDR)的表达,并报告了该基因在确定患者存活率方面的重要意义。方法:在当前研究中,我们使用真实的方法评估了32对肺癌组织和邻近非癌组织(ANCT)中VDR(,,,)的表达以及与VDR(,,)相关的5个长非编码RNA(lncRNA)的表达。时间PCR法。与匹配的ANCT相比,从男性患者获得的肿瘤组织中的表达显着降低(ER = 0.31,P值= 0.02)。但是,在女性受试者中未检测到这种模式(ER = 0.93,P值= 0.94)。与ANCT相比,LINC00346在肿瘤组织中的表达显着降低(表达比(ER)= 0.38,P值= 0.03)。根据患者的性别评估该lncRNA的表达时,其表达差异仅在男性中有显着性(ER = 0.3,P值= 0.04)。这种表达与患者的性别显着相关,其方式是大多数男性患者与配对的ANCT相比,其肿瘤组织样品中该基因的表达下调(P = 0.03)。 LINC00346的表达水平可将肺癌组织与ANCT区分,敏感性为83.3%,特异性为52.4%。与其他基因表达之间的相关性在肿瘤组织中均很明显,而在ANCT中则无关紧要。当前的研究使LINC00346可能成为肺癌发病机理的可能参与者。

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