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Halogenated Metabolites from the Diet of Aplysia dactylomela Rang

机译:海ly的饮食中的卤代代谢物

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摘要

Invertebrates are an important source of structurally-diverse and biologically-active halogenated metabolites. The sea hare Rang has long been known to possess halogenated metabolites of dietary origin that are used as a self-defense mechanism. The compounds from Rang are comprised mainly of terpenoids and small percentages of C-15 acetogenins, indoles, macrolides, sterols and alkaloids with potent cytotoxic, anti-microbial and anti-inflammatory properties. For decades the metabolites discovered have been investigated for their medical and pharmaceutical applications, so much so that the ecological role of the metabolites has been overlooked. The interaction between Rang and its diet that is comprised of seaweed can provide information into the distribution and diversity of the seaweed, the application of bioaccumulated secondary metabolites as part of its defense mechanism and the potential roles of these metabolites for adaptation in the marine environment. This paper compiles the diversity of halogenated secondary metabolites documented from Rang.
机译:无脊椎动物是结构多样且具有生物活性的卤代代谢物的重要来源。长期以来,人们都知道海兔Rang具有饮食来源的卤代代谢物,这些物质被用作自卫机制。 Rang的化合物主要由萜类化合物和少量百分数的C-15产乙酸素,吲哚类,大环内酯类,固醇类和生物碱组成,具有强大的细胞毒性,抗微生物和抗炎特性。几十年来,人们一直在研究发现的代谢物在医学和药学上的应用,以至于人们忽略了这些代谢物的生态作用。 Rang和它的由海藻组成的饮食之间的相互作用可以为海藻的分布和多样性,生物积累的次生代谢产物作为其防御机制的一部分以及这些代谢产物在海洋环境中的适应作用提供信息。本文汇编了Rang记录的卤代次生代谢物的多样性。

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