Synthesis and Bioactivity of Thiosemicarbazones Containing Adamantane Skeletons

摘要

Reaction of 4-(1-adamantyl)-3-thiosemicarbazide ( ) with numerous substituted acetophenones and benzaldehydes yielded the corresponding thiosemicarbazones containing adamantane skeletons. The synthesized compounds were evaluated for their in vitro activities against some Gram-positive and Gram-negative bacteria, and the fungus , and cytotoxicity against four cancer cell lines (Hep3B, HeLa, A549, and MCF-7). All of them showed good antifungal activity against . Compounds , , , and , , displayed significant inhibitory activity against . Compounds , , , and had moderate inhibitory potency against . Compounds , and found so good inhibitory effect on . Compounds and , which contain ( ) hydroxyl groups on the phenyl ring, were shown to be good candidates as potential agents for killing the tested cancer cell lines, i.e., Hep3B, A549, and MCF-7. Compounds – , , , , , , and were moderate inhibitors against MCF-7.