MicroRNA-106a-3p Induces Apatinib Resistance and Activates Janus-Activated Kinase 2 (JAK2)/Signal Transducer and Activator of Transcription 3 (STAT3) by Targeting the SOCS System in Gastric Cancer

机译：MicroRNA-106a-3p诱导SOCS系统靶向胃癌诱导阿帕替尼耐药并激活Janus激活激酶2（JAK2）/信号转导子和转录激活因子3（STAT3）。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Wei Guo; Wenyuan Li; Li Yuan; Xianghuang Mei; Wenqing Hu;
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作者单位

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年(卷),期 2019(25),-1
年度 2019
页码 -1
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Drug Resistance; Janus Kinase 2; MicroRNAs; STAT3 Transcription Factor; Suppressor of Cytokine Signaling Proteins;

机译：耐药性;Janus激酶2;MicroRNA;STAT3转录因子;细胞因子信号传导蛋白的抑制剂;

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专利

1. Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding. [J] . Sen B, Saigal B, Parikh N, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2009,第5期

机译：持续的Src抑制作用通过改变Janus活化的激酶-STAT3的结合，导致信号转导和转录激活因子3（STAT3）的活化以及癌细胞的存活。
2. Human epidermal growth factor receptor 2 expressions and Janus-activated kinase/signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway may be associated with clinicopathological features and prognosis of gastric cancer [J] . Wenjing Xu, Jingwei Fu, Hao Wu, Journal of Cancer Research and Therapeutics . 2018,第9期

机译：人表皮生长因子受体2的表达和Janus激活的激酶/信号转导子和转录激活子3细胞因子信号传导3通路的抑制剂可能与胃癌的临床病理特征和预后有关
3. High mobility group box 1 induces the activation of the Janus kinase 2 and signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in pancreatic acinar cells in rats, while AG490 and rapamycin inhibit their activation [J] . Guoliang Wang, Jingchao Zhang, Danhua Dui, Bosnian Journal of Basic Medical Sciences . 2016,第4期

机译：高迁移率族框1诱导大鼠胰腺腺泡细胞中Janus激酶2的激活以及信号转导和转录激活子3（JAK2 / STAT3）信号通路的激活，而AG490和雷帕霉素则抑制它们的激活
4. Expression analysis of signal transducer and activator of transcription 2 (stat2) gene in esophageal, gastric and lung cancer tissues [C] . Guang GAO, Huiling WU, Yan WU, The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议）论文集 . 2008

机译：信号转导子和转录激活因子2（stat2）基因在食管，胃和肺癌组织中的表达分析
5. Suppressor of cytokine signaling 3 blocks breast tumor kinase activation of STAT3 transcription factor. [D] . Gao, Yiwei. 2010

机译：细胞因子信号传导抑制因子3抑制STAT3转录因子激活乳腺肿瘤激酶。
6. High mobility group box 1 induces the activation of the Janus kinase 2 and signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in pancreatic acinar cells in rats while AG490 and rapamycin inhibit their activation [O] . Guoliang Wang, Jingchao Zhang, Danhua Dui, 2016

机译：高迁移率族框1诱导大鼠胰腺腺泡细胞中Janus激酶2和信号转导子及转录激活子3（JAK2 / STAT3）信号通路的激活而AG490和雷帕霉素则抑制其激活
7. High mobility group box 1 induces the activation of the Janus kinase 2 and signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in pancreatic acinar cells in rats, while AG490 and rapamycin inhibit their activation [O] . Guoliang Wang, Jingchao Zhang, Danhua Dui, 2016

机译：高迁移率组箱1诱导大鼠胰腺缩醛细胞中Janus激酶2和信号传感器和转录3（JAK2 / Stat3）信号通路的激活，而Ag490和雷帕霉素抑制它们的活化
8. Targeting Signal Transducers and Activators of Transcription-3 (STAT3) as a Novel Strategy in Sensitizing Breast Cancer to EGFR-Targeted Therapy [R] . Lo, H. 2009

机译：靶向信号转导和转录激活因子-3（sTaT3）作为敏感乳腺癌EGFR靶向治疗的新策略

MicroRNA-106a-3p Induces Apatinib Resistance and Activates Janus-Activated Kinase 2 (JAK2)/Signal Transducer and Activator of Transcription 3 (STAT3) by Targeting the SOCS System in Gastric Cancer

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