New Thiodiketopiperazine and 34-Dihydroisocoumarin Derivatives from the Marine-Derived Fungus Aspergillus terreus

摘要

has been reported to produce many secondary metabolites that exhibit potential bioactivities, such as antibiotic, hypoglycemic, and lipid-lowering activities. In the present study, two new thiodiketopiperazines, emestrins L ( ) and M ( ), together with five known analogues ( – ), and five known dihydroisocoumarins ( – ), were obtained from the marine-derived fungus RA2905. The structures of the new compounds were elucidated by analysis of the comprehensive spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HRESIMS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) data. This is the first time that the spectroscopic data of compounds , , and have been reported. Compound displayed antibacterial activity against (minimum inhibitory concentration (MIC) = 32 μg/mL) and antifungal activity against (MIC = 32 μg/mL). In addition, compound exhibited an inhibitory effect on protein tyrosine phosphatase 1 B (PTP1B), an important hypoglycemic target, with an inhibitory concentration (IC) value of 12.25 μM.