New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2

摘要

Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D–G ( – ) and letendronols A–C ( – )) as well as one known xylarinol ( ) in the cultural broth of sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemical methods, including HRESIMS, NMR, single-crystal X-ray diffraction, ECD calculation, and a modified version of Mosher’s method. Compound showed weak inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC value of 86 μM.