Arsenic trioxide ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice by inducing CD4+ T cell apoptosis

摘要

ATO ameliorates EAE progression in mice. Representative images show behavioral symptoms of EAE mice in individual groups. Black arrow presents limp tail, and red arrow presents hind limb paralysis. The clinical scores ( ) and changes in body weight ( ) were recorded. = 10 mice/group. Data are representative of three independent experiments. * < 0.05, ** < 0.01, *** < 0.001, and **** < 0.0001 the EAE group vs. the control group; + < 0.05, ++ < 0.01, and +++ < 0.001 the EAE+ATO group vs. the control group; # < 0.05 and ## < 0.01 the EAE+ATO group vs. the EAE group