Radiation myelitis after pembrolizumab administration with favorable clinical evolution and safe rechallenge: a case report and review of the literature

摘要

The radiological evolution of myelitis. and MRI performed at the time of epiduritis diagnosis, sagittal T1-weighted spin-echo and axial fat-suppressed T1 after gadolinium injection show osseous metastasis of L1 with epiduritis (but no enhancement of the spinal cord). and MRI after the first signs of myelitis, sagittal and axial fat-suppressed T1 after gadolinium injection show abnormal enhancement of the conus medullaris, and regression of osseous involvement and epiduritis. MRI at 1 month after the discontinuation of immunotherapy, sagittal T2-weighted spin-echo shows hyperintensity of the conus medullaris. MRI at 3.5 months, sagittal fat-suppressed T1 after gadolinium injection shows the persistence of conus medullaris enhancement