C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

摘要

CGRP release in vitro from two different regions isolated from the TG. The soma are located in the center of the TG ( ). The TG was cut into one area that which is fiber-rich and devoid of neuronal cell bodies (“TG fibers”) and the other that was rich in neuronal somas (“TG soma”). CGRP was increased significantly from baseline in all samples stimulated with 60 mM K (**  > 0.01, ***  n = 6 for vehicle,  = 5 for sumatriptan