Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Beta-catenin/FOXG1 complex

摘要

Elevated expression of FOXG1 is associated with metastasis in human HCC. FOXG1 mRNA levels in hepatocellular carcinoma (HCC) tissue dataset ( ). CIRR: cirrhosis tissues, HEAL: healthy liver tissues, ANT: adjacent non tumor tissues, HCC: hepatocellular carcinoma. Expression of FOXG1 mRNA and ( ) protein in LO2 normal human liver cell line (as comparison control) and the indicated cultured HCC cell lines. GAPDH was used as a loading control. Western blotting analysis of FOXG1 protein in each of the non-metastatic (N) and metastatic (M) HCC tissue from ten patients. Expression of FOXG1 protein in 64 non-metastatic (N) and 41 metastatic (M) HCC tissues. Overall survival of patients with HCC with low vs. high FOXG1 expression. Error bars represent SD from three independent experiments. *