Synthesis of calix4azacrown substituted sulphonamides with antioxidantacetylcholinesterase butyrylcholinesterase tyrosinase and carbonic anhydrase inhibitoryaction

摘要

A series of novel calix[4]azacrown substituted sulphonamide Schiff bases was synthesisedby the reaction of calix[4]azacrown aldehydes with different substituted primary andsecondary sulphonamides. The obtained novel compounds were investigated as inhibitors ofsix human (h) isoforms of carbonic anhydrases (CA, EC 4.2.1.1). Their antioxidant profilewas assayed by various bioanalytical methods. The calix[4]azacrown substitutedsulphonamide Schiff bases were also investigated as inhibitors of acetylcholinesterase(AChE), butyrylcholinesterase (BChE) and tyrosinase enzymes, associated with severaldiseases such as Alzheimer, Parkinson, and pigmentation disorders. The new sulphonamidesshowed low to moderate inhibition against hCAs, AChE, BChE, and tyrosinase enzymes.However, some of them possessed relevant antioxidant activity, comparable with standardantioxidants used in the study.