Challenging diagnoses in oral ulcers with large atypical CD30+ cells: EBV-positive mucocutaneous ulcer differentials

摘要

Ikeda T (2019) recently published an article about EBV-positive mucocutaneous ulcers (EBVMCU) in the . The authors explained many clinical and pathological aspects of this disease which pathologists must be attentive to during their diagnostic routine. At the end of the article, the authors pointed out that clinicians and pathologists need to be able to distinguish EBVMCU from lymphomas, especially classic Hodgkin lymphoma, because of the Reed-Sternberg cells with positivity for CD30. Although malignancies are important, we must not forget benign lymphoproliferations that may be a differential diagnosis for EBVMCU. The oral cavity is a good example to discuss benign and malignant differentials for EBVMCU. To that end, we wrote this letter and used two real examples of our diagnostic routine.