A210 ADLERCREUTZIA IS DEPLETED IN UC PATIENTS EVEN BEFORE CLINICAL DIAGNOSIS AND INVERSELY CORRELATES WITH FECAL ELASTOLYTIC ACTIVITY

摘要

A combination of genetics, environmental, and immune factors contribute to the development of ulcerative colitis (UC). Host proteolytic imbalance has been reported in active UC. Preliminary results from our lab suggest microbial proteolytic activity is increased before as well as after onset of UC, and transfer of this activity to mice contributes to inflammation.