Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals

摘要

Xenoestrogen datasets evaluated by exposure length, concentration, and number of experimental replicates. Datasets sorted by the incubation time of chemical exposure and graphed by xenoestrogen. Datasets grouped by incubation times ≤ 12 h (green) and > 12 h (red). Criteria for subsequent analysis ≤ 12 h. The concentration ranges of chemicals per dataset. Datasets grouped by concentrations ≤ 5 μM (green) and > 5 μM (red). Criteria for subsequent analysis ≤ 5 μM. Datasets sorted by the number of experimental replicates where ≥ 3 is depicted in green and < 3 is red. Datasets grouped by replicate number. Criteria for subsequent analysis ≥ 3. Datasets congruous with analysis criteria (incubation time, concentration range, and replicate number) were graphed by chemical (green). Datasets not meeting all three criteria are depicted in red. Datasets grouped by inclusion (green) and exclusion (red) from subsequent analysis