Impact of deoxycholate on Clostridioides difficile growth toxin production and sporulation

摘要

Bile acids play an important role in life cycle. Deoxycholate (DCA), one of the most abundant secondary bile acids, is known to inhibit vegetative growth and toxin production. However, limited data are available on the role of DCA on sporulation. Here, we investigated the phenotypic and genotypic impact of DCA on the growth, toxin production, and sporulation of .