Conditions associated with polyclonal hypergammaglobulinemia in the IgG4-related disease era: a retrospective study from a hematology tertiary care center

摘要

Hypergammaglobulinemia, the overproduction of immunoglobulins by plasma cells, is broadly divided into monoclonal and polyclonal subtypes. Monoclonal paraproteins are typically associated with plasma cell neoplasms and B-cell lymphomas such as monoclonal gammopathy of undetermined significance (MGUS), plasma cell myeloma, primary amyloidosis, chronic lymphocytic leukemia and lymphoplasmacytic lymphoma. Some rare conditions such as Schnitzler syndrome (IgM), TEMPI syndrome (IgG), and Clarkson/capillary leak syndrome (IgG) can also demonstrate a monoclonal paraprotein in the absence of a known clonal lymphocyte or plasma cell population.