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CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma

机译：CBX4通过与HDAC1相互作用而在转录水平抑制KLF6从而在透明细胞肾细胞癌中发挥致癌活性

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摘要

Dysregulation of polycomb chromobox (CBX) proteins that mediate epigenetic gene silencing contributes to the progression of human cancers. Yet their roles in clear cell renal cell carcinoma (ccRCC) remain to be explored.

机译：介导表观遗传基因沉默的多梳染色体盒（CBX）蛋白失调有助于人类癌症的发展。然而，它们在透明细胞肾细胞癌（ccRCC）中的作用仍有待探索。

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期刊名称 EBioMedicine
作者
Nan Jiang; Gang Niu; Ying-Hua Pan; Wenwei Pan; Mei-Fang Zhang; Chris Zhiyi Zhang; Huimin Shen;
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作者单位

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年(卷),期 2020(53),-1
年度 2020
页码 -1
总页数 10
原文格式 PDF
正文语种
中图分类
关键词
CBX4; KLF6; HDAC1; Combinative therapy; Clear cell renal cell carcinoma;

机译：CBX4;KLF6;HDAC1;联合治疗;透明细胞肾细胞癌;

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专利

1. Research paper CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma [J] . Nan Jiang, Gang Niu, Ying-Hua Pan, EBioMedicine . 2020,第6期

机译：研究纸张CBX4通过与HDAC1的相互作用转录抑制KLF6，以在透明细胞肾细胞癌中施加致癌活性
2. Correction: KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 [J] . Cancer research: The official organ of the American Association for Cancer Research, Inc . 2018,第5期

机译：校正：KLF6通过E2F1的转录抑制抑制透明细胞肾细胞癌的转移
3. KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 [J] . Gao Yu, Li Hongzhao, Ma Xin, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2017,第2期

机译：KLF6通过E2F1的转录抑制抑制透明细胞肾细胞癌的转移
4. Application of High-Throughput Sequencing Data Mining in Comparison of Gene Expression Profile in Renal Cell Carcinoma and Normal Renal Cell by RNA-Seq [C] . Yunhai Yu, Hongmei Xu, Shaoning Guo, International Conference on Innovative Computing . 2020

机译：高通量测序数据挖掘在RNA-SEQ肾细胞癌和正常肾细胞中基因表达谱的比较中的应用
5. Super Enhancer-associated Master Transcription Factor SOX4 Suppresses Anti-tumor Immunity in NAFLD-associated Hepatocellular Carcinoma [D] . Cheung, Ka Wing. 2019

机译：超强增强剂相关的母转录因子SOx4抑制NAFLD相关肝细胞癌中的抗肿瘤免疫力
6. The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells [O] . Martine van Keimpema, Leonie J. Grüneberg, Esther J.M. Schilder-Tol, 2017

机译：小的FOXP1亚型主要在活化的B细胞样弥漫性大B细胞淋巴瘤中表达全长FOXP1在人B细胞中发挥相似的致癌和转录活性
7. CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma [O] . Nan Jiang, Gang Niu, Ying-Hua Pan, 2020

机译：CBX4通过与HDAC1的相互作用转录抑制KLF6以在透明细胞肾细胞癌中施加致癌活性

CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma

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