Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage

摘要

Three exemplar GrC recordings are shown, one adapting, one non-adapting, one accelerating. The same color codes are used consistently in the figure. Voltage responses to 2000 ms–10 pA current injection from the holding potential of –65 mV. Spike frequency initially remains stable in all the three cells but it shows different trends thereafter. Δ and Δ are the spike frequency % changes after 500 ms and 2000 ms, respectively. In / plots, spike frequency increases almost linearly with the injected current intensity in both the accelerating, adapting, and non-adapting GrCs (  = 0.90,  = 0.0007). Plot of the intrinsic frequency change IFC vs. injected current for the three GrCs (each line represents a GrC with the same color code as in ). A positive peak is apparent in the accelerating GrC at 10 pA current injection, while negative IFC values prevail in the other GrCs.