Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro

摘要

Mechanical properties of different forms of chaperone DJ-1. QI AFM images (2 × 2 μm) showing morphological characteristics of DJ-1 , DJ-1 and  DJ-1 . – 1 mg/ml of different forms of DJ-1 were used for DLS measurement. Young’s modulus, adhesion, energy of dissipation and ANS dye-binding assay. The parameters are shown in the image , , and which were measured from three different experiments and plotted ~28 points for each form of DJ-1 from three biologically independent experiments. ** , *** , and ****