A 55-year-old man presented to the author's department with a 1-day history of abdominal pain and bloody diarrhea. Four months previously, chronic gastritis due to was diagnosed at a medical check-up. After failure of eradication by rabeprazole-amoxicillin-clarithromycin triple therapy (first-line therapy), he was started on rabeprazole-amoxicillin-metronidazole triple therapy (second-line therapy) 5 days earlier. Vital signs were normal, and his abdomen was soft. Although laboratory evaluation showed a normal leukocyte count and a C-reactive protein of 0.5 mg/dL (range <0.3), computed tomography revealed thickening of the intestinal wall from the transverse colon to splenic flexure ( ). Colonoscopy confirmed hemorrhagic and edematous mucosa ( ). A histological evaluation of specimens obtained by biopsy showed no specific findings. Antibiotic-associated hemorrhagic colitis (AAHC) was diagnosed by a positive stool culture for as well as the abovementioned findings; thus, eradication therapy was discontinued. His symptoms resolved within 2 days.
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