Subungual squamous cell carcinoma treated by topical photodynamic therapy

摘要

Squamous cell carcinoma (SCC) in the ungual apparatus is a rare neoplasm. Although it is the most prevalent malignant tumor in this region, it often presents with non-specific features that lead to misdiagnosis and delayed treatment. Various treatments have been proposed, including Mohs micrographic surgery, wide local excision with skin grafting, and amputation of the digit. Given the rarity of the condition, there is no consensus on the optimal treatment. Photodynamic therapy (PDT) has been extensively used to treat non-melanoma skin cancers, such as actinic keratosis, basal cell carcinoma, and SCC . The difficult treatment of subungual SCC and the success rates of PDT for early SCC suggested that this treatment would be useful for treating the following patient, who was diagnosed with subungual SCC but refused surgery and was ultimately successfully treated with topical PDT.