The brain–immune cells axis controls tissue specific immunopathology

摘要

Viral induction of the HPA axis increases GC levels. The HPA axis is activated early during infection with viruses, such as human  cytomegalovirus (CMV), and murine MCMV through the release of innate cytokines. Induction of the HPA leads to secretion of CRH from the hypothalamus that in turn activates the distribution of adrenocorticosterone hormone (ACTH) from the anterior pituitary. Subsequently, ACTH promotes the adrenal cortex to release GCs