Structure of the African swine fever virus major capsid protein p72

摘要

The p72 structure. Ribbon diagrams showing the structure of the p72 trimer spike. The six jelly-roll barrels and the corresponding insertion domains are colored red, green, yellow, hot pink, cornflower blue and purple, respectively. The side (left) and top (right) views showing the details of the screw propeller-like top, the central β-layer, and the pseudo hexagonal base. Diagrams showing the topology of p72. The N- and C-terminal jelly-roll barrels and the corresponding insertions are colored red and green, respectively. Ribbon diagrams showing the structure details of the insertions. Structure superposition of the ASFV p72 (red) and the faustovirus MCP (PDB: 5J7O) (cornflower blue). The N-terminal residues 1–70 of the ASFV p72 are disordered in the structure. The fitted p72 trimers (red ribbons) in the cryo-EM map (EMD-8144) of the faustovirus capsid. The map is contoured at 0.7 σ and is shown as semi-transparent solid surface. The fitted p72 trimer spikes show a zigzag arrangement of their pseudo hexagonal bases. The two jelly-roll domains of the p72 in the center is colored red and green, respectively. The p72 molecules around are all colored light blue