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摘要

Cellular senescence, a state of irreversible cell cyccycle arrest, has been foundational in the understanding of aging. It has been well studied that senescent cells also secrete inflammatory cytokines, chemokines, and growth factors. This senescence‐associated secretory phenotype (SASP) can be induced by oxidative and oncogenic genes. This phenotype reinforces cell cycle arrest as well as recruit immune cell for clearance. Cellular senescence is believed to play a role in tumor suppression, but prolonged secretion by SASP cells has been linked with cancer development and age‐related diseases, like atherosclerosis. In this review, Loo et al provide an overview of the mechanisms that cause SASP induction, with a focus of the antiviral cyclic GMP‐AMP Synthase (cGAS)‐Stimulator of Interferon Genes (STING) signaling pathway. The cGAS‐STING pathway has been shown to cause the development of HCC in obesity‐induced liver cancer cell models. This review provides a comprehensive overview of an important driver of both malignant and benign conditions.