uPAR antibody (huATN-658) and Zometa reduce breast cancer growth and skeletal lesions

摘要

is upregulated in breast and other cancers. The median expression of the human gene in normal and tumor tissues of 31 different types of cancer. Cancer abbreviations: ACC adrenocortical carcinoma, BLCA bladder urothelial carcinoma, BRCA breast invasive carcinoma, CESC cervical squamous cell carcinoma and endocervical adenocarcinoma, CHOL cholangio carcinoma, COAD colon adenocarcinoma, DLBC lymphoid neoplasm diffuse large B-cell lymphoma, ESCA esophageal carcinoma, GBM glioblastoma multiforme, HNSC head and neck squamous cell carcinoma, KICH kidney chromophobe, KIRC kidney renal clear cell carcinoma, KIRP kidney renal papillary cell carcinoma, LAML acute myeloid leukemia, LGG brain lower grade glioma, LIHC liver hepatocellular carcinoma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, OV ovarian serous cystadenocarcinoma, PAAD pancreatic adenocarcinoma, PCPG pheochromocytoma and paraganglioma, PRAD prostate adenocarcinoma, READ rectum adenocarcinoma, SARC sarcoma, SKCM skin cutaneous melanoma, STAD stomach adenocarcinoma, TGCT testicular germ cell tumors, THCA thyroid carcinoma, THYM thymoma, UCEC uterine corpus endometrial carcinoma, UCS uterine carcinosarcoma. The cancer types where expression is significantly upregulated and downregulated in tumor tissues relative to adjacent normal tissues are marked by ‘red’ and ‘green’ asterisks, respectively. The expression is elevated in all subtypes of breast cancer. Significant differences are represented by asterisks (*  c Kaplan–Meier survival curve using gene expression datasets of 1 746 breast cancer patients shows that higher expression of the gene is associated with a significantly poor distant metastasis-free survival (DMFS). The microarray-based gene expression values from the 1 764 patients were divided into two groups based on the median expression of the gene. In this case, the cutoff value was 282 (automatically done by the KM-plotter algorithm) while the expression range of the probe was between 23 and 1 191. Based on this cutoff value, gene expressions in 1 301 out of the 1 746 patients were analyzed in the low expression group while expression values from 445 patients were analyzed in the high expression group during DMFS analysis