Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop

摘要

Melatonin delays the progression of IVDD in vivo. , MRI images and Pfirrmann grade analysis of the rat models at 4 or 8 weeks after the operation. , H&E staining, Safranin-O staining and histologic score analysis of the rat models at 8 weeks after the operation (original magnification ×10, ×50; scale bar = 500 µm, 200 µm). , IHC staining and quantitative analysis of Aggrecan and Collagen II in IVDD rats treated with melatonin (original magnification ×400; scale bar = 50 µm). Behavioral study of the rat models at different time points after the operation. CTR, Control.  = 5, *  P #