Investigation of sequence features of hinge-bending regions in proteins with domain movements using kernel logistic regression

摘要

DynDom result for glutamine binding protein. DynDom result for the movement that occurs upon binding glutamine (PDB: 1GGG, chain A to PDB: 1WDN, chain A) showing the open, ligand-free conformation (see DynDom website at for more details on this and other domain movements). The arrow represents the hinge axis. Red and blue are the dynamic domains, green the hinge-bending regions. Red and blue amino acids in the sequence at the bottom of the figure are intradomain and green amino acids are hinge-bending. Such annotated sequences are the basic data of this study. This is a typical member of Group 1 (see )