The Relation between Polymorphisms in Exon 5 and Exon 6 of GSTP1 Gene and the Risk of Lung Cancer in Iranian People

摘要

The gene, which is located on chromosome 11q13, consists of 7 exons and 6 introns. There are two polymorphisms in that have been exposed to a transposition for codon 105 (Ile/Val) and 114 (Ala/Val) in exons 5 and 6, which have been studied previously in relation to lung cancer. Since the level of expression in lung tissues and other human epithelial tissues is high, polymorphism is recognized as a sensitive factor for tobacco-related cancers, especially lung cancer.