Allele Frequency of the C.5GA Mutation in the PRCD Gene Responsible for Progressive Retinal Atrophy in English Cocker Spaniel Dogs

摘要

Progressive retinal atrophy (PRA) in English cocker spaniels (ECSs) is associated with progressive rod–cone degeneration (prcd-PRA), an inherited autosomal recessive disease caused by the c.5G>A mutation in the progressive rod–cone degeneration ( ) gene. Data regarding the prevalence of the mutated allele are scarce in the global literature, and there is no study evaluating this frequency in Brazil. Therefore, the aim of this study was to evaluate the allele frequency of the c.5G>A mutation in the gene responsible for progressive retinal atrophy (prcd-PRA) in ECS dogs.