Oxidative Stress and Inflammation in Sows with Excess Backfat: Up-Regulated Cytokine Expression and Elevated Oxidative Stress Biomarkers in Placenta

摘要

Maternal obesity is associated with increased farrowing difficulties and influences the fetus, but the effect on placental inflammation, oxidative stress, and vascular development in swine remains unclear. In this study, we tested the hypothesis that maternal obesity blocks placental vascular development associated with maternal obesity-increased placental inflammation and oxidative stress in swine. The objective of this study was to evaluate the influence of body condition of sows to placental pro-inflammatory and oxidative stress status and placental angiogenesis. we found that higher backfat thickness in sows is associated with enhanced oxidative stress, increased expression of pro-inflammation cytokines, and inhibited angiogenesis in the placenta. Therefore, reasonable control of body conditions during reproductive cycles may improve placenta development and maintain a healthy placenta environment.