MicroRNA Detection: Single Functionalized pRNA/Gold Nanoparticle for Ultrasensitive MicroRNA Detection Using Electrochemical Surface‐Enhanced Raman Spectroscopy (Adv. Sci. 3/2020)

摘要

In article number , Peixuan Guo, Jeong‐Woo Choi, and co‐workers fabricate monofunctionalized gold nanoparticles (AuNPs) with a single copy of an RNA three‐way junction (3WJ) motif for application in ultra‐sensitive miRNA biosensing using electrochemical surface‐enhanced Raman spectroscopy (EC‐SERS). In the presence of miRNA‐155, miRNA‐155 displaces the 3WJ structure and it results in a remarkable increase in the electrochemical and SERS signals.