Efficient Route to C2 Symmetric Heterocyclic Backbone Modified Cyclic Peptides

摘要

A tandem dimerization–macrocyclization approach using 1,3-dipolar azide–alkyne cycloaddition reactions has been employed in the facile and convergent solution phase syntheses of C2 symmetric cyclic peptide scaffolds bearing triazole ε-amino acids as dipeptide surrogates.