Novel Approach to Multifunctionalized Homoallylic Alcohols via Regioselective Ring Opening of Aryl Oxiranes with 3-Iodo Allenoates

摘要

3-Iodo allenoates were generated in situ and utilized, for the first time, in the ring opening of oxiranes in a regioselective fashion. This simple one-pot three-component reaction protocol provides an easy access to highly functionalized homoallylic alcohols in good yields and moderate to very good (Z:E) selectivity. The two functional groups (ester and halogen) can be further subjected to many synthetic transformations.