Are population pharmacokinetic and/or pharmacodynamic models adequately evaluated? A survey of the literature from 2002 to 2004

摘要

PurposeModel evaluation is an important issue in population analyses. We aimed to perform a systematic review of all population PK and/or PD analyses published between 2002 and 2004 to survey the current methods used to evaluate a model and to assess whether those models were adequately evaluated.