Synthesis of (-)-Δ9-trans-Tetrahydrocannabinol - Stereocontrol via Mo-catalyzed Asymmetric Allylic Alkylation Reaction

摘要

Δ⁹-THC is synthesized in enantiomericaly pure form, where all of the stereochemistry is derived from the molybdenum catalyzed asymmetric alkylation reaction of the extremely sterically congested bis-ortho substituted cinnamyl carbonate in high regio- and enantioselectivity.